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Use AI to optimize your health system’s 340B program

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Artificial intelligence (AI) is transforming healthcare, offering innovative ways to enhance operations, improve outcomes, and reduce inefficiencies. For health systems managing a 340B program, AI presents a unique opportunity to streamline processes, ensure compliance, and optimize savings. However, successful implementation requires a strategic and tailored approach, particularly when incorporating entity-owned pharmacies, pharmacy services partners, and contract pharmacy optimization.

Identify key challenges and opportunities

Begin by assessing specific pain points within your 340B program. Common challenges include compliance monitoring, claim matching, and inventory management. AI can address these issues by automating repetitive tasks, reducing human error, and providing real-time insights. For instance, AI tools can predict replenishment needs for entity-owned pharmacies, helping maintain inventory levels while minimizing waste. Similarly, automated systems can enhance claims matching accuracy, ensuring compliance with HRSA audit requirements.

    Partner with experts

    Health systems often work with pharmacy services partners to manage operations efficiently. These partners can play a crucial role in implementing AI by providing expertise, infrastructure, and access to advanced tools. Collaborate with your partner to identify AI solutions that align with your program’s goals. For example, they can assist in integrating AI-driven compliance software to monitor contract pharmacy activities, flagging potential discrepancies before they become larger issues.

    Optimize contract pharmacy arrangements

    Contract pharmacy networks can be complex, but AI offers tools to maximize their potential. Machine learning algorithms can analyze transaction data across multiple contract pharmacies, identifying patterns and opportunities to improve revenue capture and compliance. By leveraging AI, health systems can gain insights into underperforming sites, optimize pricing strategies, and improve coordination between entity-owned and contract pharmacies.

    Implement thoughtfully

    Introducing AI into your 340B program is not a one-size-fits-all solution. Begin with a pilot project targeting a well-defined challenge. For instance, start with compliance automation for a single entity-owned pharmacy or a subset of contract pharmacies. Monitor the tool’s effectiveness and gather feedback from stakeholders. Verify that the AI integrates seamlessly with existing systems, including pharmacy management software and third-party platforms.

    Measure and adjust

    The implementation of AI is an iterative process. Regularly assess its performance against key metrics, such as compliance rates, error reductions, and financial outcomes. Use this data to refine your approach and expand AI applications across other areas of the 340B program. Maintaining alignment with HRSA audit expectations is critical, so work closely with legal and compliance teams to address evolving regulations.

    Final thoughts

    By leveraging AI strategically, health systems can enhance the efficiency and impact of their 340B programs. From optimizing entity-owned and contract pharmacies to collaborating with pharmacy services partners, the right AI tools can drive measurable improvements in compliance, savings, and operational performance. Thoughtful implementation and continuous evaluation help these technologies deliver long-term value.

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